Some Recent Publications
1. Leo MD, Bannister JP, Narayanan D, Nair A, Grubbs JE, Gabrick KS, Boop FA, Jaggar JH. Dynamic Regulation of β1 subunit Trafficking Controls Vascular Contractility. Proc. Natl. Acad. Sci. USA 2014; 111(6):2361-2366. PMID: 24464482
2. Evanson, KW, Bannister JP, Leo MD, Jaggar JH. LRRC26 is a functional BK channel auxiliary γ subunit in arterial smooth muscle cells. Circ Res 2014; 115(4):423-341. PMID: 24906643
3. Kidd MW, Leo MD, Bannister JP, Jaggar JH. Intravascular pressure enhances the abundance of functional Kv1.5 channels at the surface of arterial smooth muscle cells. Science Signaling 2015; 8(390):ra83. doi: 10.1126/scisignal.aac5128. PMID: 26286025
4. Leo MD, Zhai X, Muralidharan P, Kuruvilla KP, Bulley S, Boop FA and Jaggar JH. Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction. Science Signaling 2017; 10, eaah5417. PMID: 28487419.
Cover Story and Associated Podcast.
5. Zhai X, Leo, MD and Jaggar JH. Endothelin-1 stimulates vasoconstriction through Rab11A serine 177 phosphorylation. Circ Res 2017; 121(6):650-661. doi: 10.1161/CIRCRESAHA.117.311102 PMID: 28696251.
6. Bulley S*, Fernández-Peña C*, Hasan R, Leo MD, Muralidharan P, MacKay CE, Evanson CW, Moreira-Junior L, Mata-Daboin A, Burris SK, Wang Q, Kuruvilla KP and Jaggar JH. Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. eLife 2018; 4;7. pii: e42628. doi: 10.7554/eLife.42628. * contributed equally. PMID: 30511640.
The AAAS: https://www.eurekalert.org/pub_releases/2018-12/e-ndt120518.php
Science Daily: https://www.sciencedaily.com/releases/2018/12/181205134042.htm
ALN: https://www.laboratoryequipment.com/article/2018/12/mouse-research-identifies-possible-drug-target-high-blood-pressure
PNAS Journal Club: Ion channel puts the squeeze on blood vessels, affecting blood pressure.
7. Hasan R*, Leo MD*, Muralidharan P, Mata-Daboin A, Yin W, Bulley S, Fernandez-Peña C, MacKay C and Jaggar JH. SUMO1-modification of PKD2 channels regulates arterial contractility. Proc. Natl. Acad. Sci. USA 2019 116 (52) 27095-27104. PMID: 31822608. * contributed equally.
8. MacKay CE, Leo MD, Fernández-Peña C, Hasan R, Yin W, Mata-Daboin A, Bulley S, Gammons J, Mancarella S, Jaggar JH. Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure. eLife 2020; 9:e56655. doi: 10.7554/eLife.56655. PMID: 32364494.
9. MacKay CE, Floen M, Leo MD, Hasan R, Garrud TAC, Fernández-Peña C, Singh, P, Malik, KU and Jaggar JH. A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation. eLife 2022 Mar 1;11:e74765. doi: 10.7554/eLife.74765. PMID: 35229718.
